背景：TGF-beta 1 is a member of the transforming growth factor beta （TGF-beta） family.
The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death.
TGF-beta 1 positively and negatively regulates many other growth factors.
It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins.
It can also decrease the expression levels of cytokine receptors.
Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature.
TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells.
As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates.
However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin.
TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types.
It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis.
Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
仕様
サイズ：100ug
種由来：Rat
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P17246
アミノ酸配列：Ala279-Ser390
遺伝子構造：A DNA sequence encoding the rat TGFB1 （P17246）（Ala279-Ser390） was expressed. Rat and Mouse mature TGFB1 sequences are identical.
別名（遺伝子名）：TGF-beta 1;TGFB;TGFbeta
分子量：12.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
