背景：FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG.
The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99％ sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains.
FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.
FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif （ITIM） and delivers an inhibitory signal upon ligand binding.
Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis.
Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation.
FcγRIIB may also be a target for monoclonal antibody therapy for malignancies.
FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
仕様
サイズ：1mg
種由来：Rat
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q63203-1
アミノ酸配列：Met 1-Pro 212
遺伝子構造：A DNA sequence encoding the rat FCGR2B （Q63203-1） extracellular domain （Met 1-Pro 212） was expressed, fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：FCRII;Fcgr2
分子量：21.9 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
