背景：Thrombomodulin, also known as THBD（CD141）, is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.
Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin.
It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1：1 stoichiometric complex with thrombin.
Thrombomodulin also regulates C3b inactivation by factor I.
Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
仕様
サイズ：50ug
種由来：Rat
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O35370
アミノ酸配列：Met1-Ser517
遺伝子構造：A DNA sequence encoding the rat THBD （O35370） （Met1-Ser517） was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：THBD
分子量：55.2 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
