84-9374-40　［取扱停止］Recombinant Rabbit IL21 protein（His tag） 50ug　PKSQ500008

特徴

• 背景：IL21 belongs to the IL-15/IL-21 family.
• It is a cytokine with immunoregulatory activity.
• Cytokines are proteinaceous signaling compounds that are major mediators of the immune response.
• They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.
• Cytokines are synthesized under various stimuli by a variety of cells of both the innate （monocytes, macrophages, dendritic cells） and adaptive （T- and B-cells） immune systems.
• IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
• It may promote the transition between innate and adaptive immunity.
• IL-21 has been tried as a therapy for alleviating allergic responses.
• It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis （nasal passage inflammation）.