背景：NKG2-D type II integral membrane protein （NKG2D） is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family.
NKG2D is expressed on natural killer （NK） cells, CD8+ alpha-beta and gamma-delta T-cells.
As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells.
It provides both stimulatory and costimulatory innate immune responses on activated killer （NK） cells, leading to cytotoxic activity.
It stimulates perforin-mediated elimination of ligand-expressing tumor cells.
Signaling involves calcium influx, culminating in the expression of TNF-alpha.
NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells.
It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 （ULBP2＞ULBP1＞ULBP3） and ULBP4.
仕様
サイズ：10ug
種由来：Cynomolgus macaques
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P61252
アミノ酸配列：Phe78-Val216
遺伝子構造：Recombinant Cynomolgus NKG2-D type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe78-Val216 is expressed with a 6His tag at the N-terminus.
別名（遺伝子名）：CD314; KLRK1; CD314 antigen; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D
分子量：16.9 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
