84-9374-08 ［取扱停止］Recombinant Mouse S100a8 protein （His Tag） 20ug PKSM500008
[Elabscience]
特徴
- 背景：S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.
- It can induce neutrophil chemotaxis and adhesion.
- Predominantly found as calprotectin （S100A8/A9） which has a wide plethora of intra- and extracellular functions.
- The intracellular functions include： facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
- Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX.
- The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.
- Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞90 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションNo.：P27005
- アミノ酸配列：Pro2-Glu89
- 遺伝子構造：A DNA sequence encoding the Mouse S100a8 protein（P27005） （2P-89G） was expressed with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：60B8AG, CAGA, Calgranulin A, Calprotectin L1L subunit, CFAG, CGLA, CP 10, Cystic fibrosis antigen, L1Ag, MA387, MIF, MRP-8, MRP8, NIF, P8, Protein S100-A8, S100A8, Urinary stone protein band A,Pro-inflammatory S100 cytokine,S100 calcium-binding protein A8
- 分子量：11.5kDa
- 組成：Lyophilized from sterile PBS, pH 7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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84-9352-51
Recombinant Mouse S100a8 protein （His Tag） 100ug
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84-9374-08
Recombinant Mouse S100a8 protein （His Tag） 20ug
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84-9352-50
Recombinant Mouse S100a8 protein （His Tag） 20ug
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