84-9373-89　Recombinant Mouse CD27L protein（N-His）（active） 20ug　PKSM041517

特徴

• 背景：CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells.
• Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation.
• Tight control of CD70 expression is required to prevent lethal immunodeficiency.
• By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells （DC）.
• As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation.
• Immunohistochemical analysis of CD70 expression in multiple carcinoma types.
• The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics.
• Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.