特徴
- 背景：Cerebral Dopamine Neurotrophic Factor （CDNF）, also known as ARMETL1 （ARMET-like protein 1）, is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family.
- CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor （GDNF）.
- CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease.
- CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum.
- Human CDNF is glycosylated and secreted from transiently transfected cells.
- CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞98 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜0.1 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：Q8CC36
- アミノ酸配列：MRCISPTALVTFCAGFCISNPVLAQGLEAGVGPRADCEVCKEFLDRFYNSLLSRGIDFSADTIEKELLNFCSDAKGKENRLCYYLGATTDAATKILGEVTRPMSVHIPAVKICEKLKKMDSQICELKYGKKLDLASVDLWKMRVAELKQILQRWGEECRACAEKSDYVNLIRELAPKYVEIYPQTEL
- 別名（遺伝子名）：9330140G23;Armetl1
- 分子量：21.86 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9373-76
Recombinant Mouse CDNF protein（N-His） 100ug
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84-9373-75
Recombinant Mouse CDNF protein（N-His） 20ug
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