84-9372-90　Recombinant Mouse IL-20 protein（N-His）（active） 20ug　PKSM041468

特徴

• 背景：Interleukin-20 （IL-20） is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26.
• Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions.
• IL-20 exhibits approximately 28％ amino acid identity with IL-10 and 76％ amino acid identity with mouse IL-20.
• There are two heterodimeric receptor complexes for IL-20.
• The first is composed of IL-20 Rα and IL-20 Rβ.
• The second is composed of IL-22 R and IL-20 Rβ.
• Whereas the IL-22 R/IL-20 Rβ complex is shared with IL-24, the IL-20 Rα/IL-20 Rβ complex is shared with both IL-19 and IL-24.
• IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF-α and MCP-1.
• Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development.
• The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality.
• In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis.
• IL-20 may also have a role in hematopoiesis.
• It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice.
• IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.