84-9372-84 ［取扱停止］Recombinant Mouse IL-12 p40 protein（N-His）（active） 20ug PKSM041465
[Elabscience]
特徴
- 背景：Interleukin 12 （IL-12） is the founding member of the IL-12 family of heterodimeric cytokines, which have important immunological functions.
- IL-12 is composed of two disulfide-linkedsubunits of 35 kDa and 40 kDa, respectively.
- The 35 kDa subunit （p35） is an α-helical protein homologous to IL-6 and GCSF.The 40 kDa subunit（p40） contains one fibronectin type III and one Ig C2-like domain, and has a high degree of structural homology to type I cytokine receptors.
- Whereas p35 subunit is unique to IL-12,the p40 subunit is also utilized in IL-23.Mature rat p35 is a 194 amino acids （aa） protein that is secreted as a heterodimer linked to p40.
- It contains three potential N-linked glycosylation sites and shares 86％, and 58％ aa sequence identity with mouse and human p35, respectively.
- Mature rat p40 contains 313 aa and can exist in multiple forms, including monomer, homodimer, heterodimer linked to p19 （forming IL23）, and heterodimer linked to p35 （forming IL-12）.
- IL12 facilitates hematopoietic stem cell proliferation, induces NK cell proliferation, and potentiates the expansion and late activation of Th1 CD4+ T cells.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞98 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜0.1 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P43432
- アミノ酸配列：MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS
- 別名（遺伝子名）：Interleukin-12 subunit beta, IL-12 subunit p40, IL-12B, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit （CLMF p40）, NK cell Stimulating Factor Chain 2
- 分子量：39.06 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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84-9372-85
Recombinant Mouse IL-12 p40 protein（N-His）（active） 100ug
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84-9372-84
Recombinant Mouse IL-12 p40 protein（N-His）（active） 20ug
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