84-9372-82　［取扱停止］Recombinant Mouse IL-12 p35 protein（N-His）（active） 20ug　PKSM041464

特徴

• 背景：Interleukin 12 （IL-12） is the founding member of the IL-12 family of heterodimeric cytokines, which have important immunological functions.
• IL-12 is composed of two disulfide-linkedsubunits of 35 kDa and 40 kDa, respectively.
• The 35 kDa subunit （p35） is an α-helical protein homologous to IL-6 and GCSF.The 40 kDa subunit（p40） contains one fibronectin type III and one Ig C2-like domain, and has a high degree of structural homology to type I cytokine receptors.
• Whereas p35 subunit is unique to IL-12,the p40 subunit is also utilized in IL-23.Mature rat p35 is a 194 amino acids （aa） protein that is secreted as a heterodimer linked to p40.
• It contains three potential N-linked glycosylation sites and shares 86％, and 58％ aa sequence identity with mouse and human p35, respectively.
• Mature rat p40 contains 313 aa and can exist in multiple forms, including monomer, homodimer, heterodimer linked to p19 （forming IL23）, and heterodimer linked to p35 （forming IL-12）.
• IL12 facilitates hematopoietic stem cell proliferation, induces NK cell proliferation, and potentiates the expansion and late activation of Th1 CD4+ T cells.