背景：Interleukin-4 receptor subunit alpha（IL-4RA）, alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily.
It expressed in both Th1 and Th2 cells.
It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway.
The IL4 response is involved in promoting Th2 differentiation.
The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation.
In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2.
The functional IL4 receptor is formed by initial binding of IL4 to IL4R.
Subsequently it recruits to the complex of the common gamma chain.
In immune cells, IL-4RA creates a type I receptor.
In non-immune cells, it forms a type II receptor with of IL13RA1.
IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.
仕様
サイズ：10ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P16382
アミノ酸配列：Ile26-Arg233
遺伝子構造：Recombinant Mouse Interleukin-4 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Ile26-Arg233 is expressed with a 6His tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
