背景：Siglecs （sialic acid binding Ig-like lectins） are I-type （Ig-type） lectins belonging to the Ig superfamily.
They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains.
Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule （BL-CAM）, is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells.
Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated.
Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same （cis） or adjacent （trans） cells.
Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.
仕様
サイズ：10ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P35329
アミノ酸配列：Ser22-Arg702
遺伝子構造：Recombinant Mouse B-cell Receptor CD22 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg702 is expressed with a 6His tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
