特徴
- 背景：Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance.
- Leptin functions via signaling pathways involving OB-R in hypothalamus.
- Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level.
- When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes.
- Leptin deficiency reduces metablic rate.
- Leptin deficient mice are less active and with lower body temperature than normal animals.
- Human Leptin shares approximately 84％ sequence identity with the mouse protein.
- Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：Q544U0
- アミノ酸配列：Val22-Cys167
- 遺伝子構造：Recombinant Mouse Leptin is produced by our E.coli expression system and the target gene encoding Val22-Cys167 is expressed.
- 別名（遺伝子名）：Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS
- 分子量：16.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.5.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9372-70
Recombinant Mouse Leptin 50ug
|
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84-9372-69
Recombinant Mouse Leptin 10ug
|
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