背景：Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family.
Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain.
Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival.
Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness.
It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses.
Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer.
The receptor tyrosine kinase AXL is thought to play a role in metastasis.
The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer.
GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
仕様
サイズ：10ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q00993
アミノ酸配列：Ala26-Pro440
遺伝子構造：Recombinant Mouse Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala19-Pro443 is expressed with a 6His tag at the C-terminus.
別名（遺伝子名）：Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO
分子量：47.2 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
