背景：Tumor necrosis factor receptor superfamily, member 13C （TNFRSF13C） also known as B-cell-activating factor receptor （BAFFR） and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily.
BAFF promotes the survival of B cells and is essential for B cell maturation.
BAFF binds to three TNF receptor superfamily members： B-cell maturation antigen （BCMA/TNFRSF17）, transmembrane activator and calcium-modulator and cyclophilin ligand interactor （TACI/TNFRSF13B） and BAFF receptor （BAFF R/BR3/TNFRSF13C）.
These receptors are type III transmembrane proteins that lack a signal peptide.
BAFF R is highly expressed in spleen, lymph node and resting B cells.
It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes.
BAFF knockout mice lack mature B cells.
Similarly, A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis.
It has been proposed that abnormally high levels of BAFFR/TNFRSF13C （CD268） may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
仕様
サイズ：10ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9D8D0
アミノ酸配列：Ser10-Ala 71
遺伝子構造：Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 13C is produced by our Mammalian expression system and the target gene encoding Ser10-Ala 71 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：BAFF R; BAFFR; BR3; CD268; TNFRSF13C
分子量：33.8 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
