特徴
- 背景：Mouse Interleukin-4（IL-4） is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses.
- It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α-helix structure.
- IL-4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types.
- IL-4 is primarily expressed by Th2-biased CD4+T cells, mast cells, basophils, and eosinophils.
- It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by na?ve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells.
- IL-4 plays a dominant role in the development of allergic inflammation and asthma.
- It also regulates the expression of the low affinity Fc receptor for IgE （CD23） on both lymphocytes and monocytes.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P07750
- アミノ酸配列：His23-Ser140
- 遺伝子構造：Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.
- 別名（遺伝子名）：Interleukin-4;B-cell IgG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;IGG1 induction factor;Lymphocyte stimulatory factor 1;IL-4;BSF-1
- 分子量：13.4 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9372-36
Recombinant Mouse Interleukin-4/IL-4 Protein 100ug
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84-9372-35
Recombinant Mouse Interleukin-4/IL-4 Protein 20ug
|
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