84-9372-28 Recombinant Mouse Interleukin-18/IL-18 Protein （His Tag） 100ug PKSM041079
[Elabscience]
特徴
- 背景：Interleukin-18 （IL-18）is a protein which belongs to the IL-1 family.
- It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes.
- Mature mouse IL-18 shares 63％ and 91％ amino acid sequence identity with mouse and rat IL-18, respectively.
- IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex.
- Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs.
- It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
- In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells.
- In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P70380
- アミノ酸配列：Asn36-Ser192
- 遺伝子構造：Recombinant Mouse Interleukin-18 is produced by our E.coli expression system and the target gene encoding Asn36-Ser192 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Interleukin-18;Il18;Interferon gamma-inducing factor;IFN-gamma-inducing factor;Interleukin-1 gamma;IL-1 gamma;Igif
- 分子量：19.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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| 商品イメージ | アズワン品番 商品名 |
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84-9372-28
Recombinant Mouse Interleukin-18/IL-18 Protein （His Tag） 100ug
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84-9372-27
Recombinant Mouse Interleukin-18/IL-18 Protein （His Tag） 20ug
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