特徴
- 背景：Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha （chemokine CxC） family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs.
- Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis.
- It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1.
- Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
- Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase.
- It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins.
- SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase.
- It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P40224
- アミノ酸配列：Lys22-Lys89
- 遺伝子構造：Recombinant Mouse C-X-C motif chemokine 12 is produced by our E.coli expression system and the target gene encoding Lys22-Lys89 is expressed.
- 別名（遺伝子名）：Cxcl12;Stromal cell-derived factor 1;SDF-1;12-O-tetradecanoylphorbol 13-acetate repressed protein 1;TPAR1;C-X-C motif chemokine 12;Pre-B cell growth-stimulating factor;PBSF;Thymic lymphoma cell-stimulating factor;TLSF;Sdf1
- 分子量：8.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9372-12
Recombinant Mouse CXCL12/SDF-1 Protein 100ug
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84-9372-11
Recombinant Mouse CXCL12/SDF-1 Protein 20ug
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