特徴
- 背景：C-C Motif Chemokine 3 （MIP-1 alpha,CCL3 ） is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta.
- CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells.
- Mature mouse CCL3 shares 73％, 91％, and 82％ amino acid sequence identity with human, rat, and cotton rat CCL3, respectively.
- CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5.
- It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6.
- CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils.
- CCL3 is also known as stem cell inhibitor （SCI） and can inhibit the proliferation of hematopoietic progenitor cells.
- CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the replication of HIV.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P10855
- アミノ酸配列：Ala24-Ala92
- 遺伝子構造：Recombinant Mouse C-C Motif Chemokine 3 is produced by our E.coli expression system and the target gene encoding Ala24-Ala92 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：C-C motif chemokine 3;Heparin-binding chemotaxis protein; Macrophage inflammatory protein 1-alpha;MIP1-a; chemokine （C-C motif） ligand 3; LD78a; LD78 alpha; MIP-1 alpha;Scya3
- 分子量：10.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5％Trehalose,1mM EDTA,pH8.0.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9372-09
Recombinant Mouse CCL3 Protein （His Tag） 20ug
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84-9372-10
Recombinant Mouse CCL3 Protein （His Tag） 100ug
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