背景：IL17, also known as IL17a, is a cytokine belongs to the IL-17 family.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response.
They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.
Cytokines are synthesized under various stimuli by a variety of cells of both the innate （monocytes, macrophages, dendritic cells） and adaptive （T- and B-cells） immune systems.
The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types.
IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases.
This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 （PTGS2/COX-2）, as well as enhance the production of nitric oxide （NO）.
High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仕様
サイズ：100ug
種由来：Mouse
発現宿主：E.coli
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：Q62386
アミノ酸配列：Thr 22-Ala158
遺伝子構造：A DNA sequence encoding the mature form of mouse IL17a （Q62386） （Thr 22-Ala158） was expressed and purified.
別名（遺伝子名）：Ctla-8;Ctla8;IL-17;IL-17A;Il17
分子量：15.5 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
