背景：High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily.
CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses.
Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16.
CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail.
CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells.
The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions.
Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_034316.1
アミノ酸配列：Met 1-Pro 297
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Pro 297） of mouse FCGR1 （NP_034316.1） precursor was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; CD64;FcgammaRI;IGGHAFC
分子量：32 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
