背景：Programmed death-1 ligand-1 （PD-L1, CD274, B7-H1） has been identified as the ligand for the immunoinhibitory receptor programmed death-1（PD1/PDCD1） and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells.
By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers.
PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞98 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_068693.1
アミノ酸配列：Met 1-Thr 238
遺伝子構造：A DNA sequence encoding the mouse CD274 （NP_068693.1） extracellular domain （Met 1-Thr 238） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
