背景:The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping.
Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell.
There are more than 320 CD unique clusters and subclusters have been identified.
Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell.
Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion.
Cluster of differentiation 14 (CD14) is a member of the CD system.
It takes its name from its inclusion in the CD molecule surface marker proteins.
CD14 exists in two forms: a form anchored into the membrane or a soluble form.
CD14 was found expressed in macrophages, neutrophil granulocyte and dendritic cells.
The major function is serve as a co-receptor (along with TLR4 and MD-2) for the bacterial lipopolysaccharide (LPS) and other pathogen-associated molecular patterns.
仕様
サイズ:1mg
種由来:Mouse
発現宿主:HEK293 Cells
純度:>97 % as determined by reducing SDS-PAGE.
エンドトキシン濃度:<1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.:NP_033971.1
アミノ酸配列:Met 1-Pro 345
遺伝子構造:A DNA sequence encoding the extracellular domain (Met 1-Pro 345) of mouse CD14 (NP_033971.1) precursor was fused with a polyhistidine tag at the C-terminus.
別名(遺伝子名):CD14
分子量:36.8 kDa
組成:Lyophilized from sterile PBS, pH 7.4
保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.