背景：Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses.
Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc.
Three groups are included for Fc γ receptors （FcR）, and they are Fc γ RI （CD64）, Fc γ RII （CD32）, and Fc γ RIII （CD16）.
Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity for IgG.
Genes encodes these receptors are diverse differing by species and cell types.
The aggregation of FcR having immunoreceptor tyrosine-based activation motifs （ITAMs） activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors.
FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis.
Fcgr4 belongs to Fc γ RIII （CD16） group.
仕様
サイズ：100ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_653142.2
アミノ酸配列：Met 1-Gln 203
遺伝子構造：The amino acid sequence corronding to （Met 1-Gln 203） of mouse FCGR4 （NP_653142.2） was fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase （BirA enzyme） which is co-expressed.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
