背景：Choanal （CA） and gastrointestinal atresias （GA） are an important feature of syndromic congenital sodium diarrhea （sCSD）, a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 （SPINT2）.
The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression.
SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase.
Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation.
SPINT2 （serine peptidase inhibitor Kunitz type 2）, a proteolytic inhibitor of hepatocyte growth factor activator （HGFA）, which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.
仕様
サイズ：50ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001076017.1
アミノ酸配列：Met 1-Lys 140
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Lys 140） of mouse SPINT2 （NP_001076017.1） precursor was expressed with a C-terminal polyhistidine tag.
別名（遺伝子名）：AL024025;C76321;HAI-2
分子量：14 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
