背景：CD28（Cluster of Differentiation 28） is a disulphide-bonded glycoprotein belonging to the immunoglobulin （Ig） superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain.
Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers.
CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways.
B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance.
CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_031668.3
アミノ酸配列：Met 1-Lys 149
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Lys 149） of mouse CD28 （NP_031668.3） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
