背景：Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2.
PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-＆gamma; by suppressing the activation and transduction of PI3K/AKT pathway.
In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.
PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases.
Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection.
As a cell surface molecule, PDCD1 regulates the adaptive immune response.
Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_032824.1
アミノ酸配列：Met 1-Gln 167
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Gln 167） of mouse PDCD1 （NP_032824.1） precursor was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Ly101;PD-1;Pdc1
分子量：17.6 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
