背景：Vascular cell adhesion molecule 1 （VCAM-1）, also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily.
Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant.
VCAM-1 is an endothelial ligand for very late antigen-4 （VLA-4） and ＆alpha;4＆szlig;7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction.
VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses.
During these responses, VCAM-1 forms a scaffold for leukocyte migration.
VCAM-1 also activates signals within endothelial cells resulting in the opening of an ＆quot;endothelial cell gate＆quot; through which leukocytes migrate.
VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis.
In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_035823.3
アミノ酸配列：Met 1-Glu 698
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Glu 698） of mouse VCAM1 （NP_035823.3） was fused with the a polyhistidine tag at the C-terminus.
別名（遺伝子名）：CD106;Vascular cell adhesion protein 1; Vcam1; L1CAM;VCMA1;Vcam-1
分子量：75.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
