背景：Inducible co-stimulator ligand （ICOSL）, also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2.
It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function.
The structural features of ICOSL are crucial for its costimulatory function.
Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2.
B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production.
The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses.
Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_056605.1
アミノ酸配列：Met 1-Lys 279
遺伝子構造：A DNA sequence encoding the mouse B7-H2 （NP_056605.1） extracellular domain （Met 1-Lys 279） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
