84-9371-71　Recombinant Mouse PSMA/FOLH1 Protein （His Tag） 1mg　PKSM040800

特徴

• 背景：Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily.
• FOLH1 is highly expressed in prostate epithelium.
• It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain （at protein level）, and the capillary endothelium of a variety of tumors.
• FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase （NAALADase） activity.
• It has a preference for tri-alpha-glutamate peptides.
• Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia.
• This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits.
• FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.