84-9371-67　Recombinant Mouse CD73/NT5E Protein （His Tag）（Active） 50ug　PKSM040791

特徴

• 背景：5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein which belongs to the5'-nucleotidase family.
• CD73 is a glycosyl phosphatidylinositol （GPI） anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes.
• CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides.
• CD73 serves as a costimulatory molecule in activating T cells.
• CD73 generated adenosine functions in cell signalling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses.
• CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function.
• In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1 and E-selectin increase.
• CD73 produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses.
• CD73 has also been reported to regulate expression of pro-inflammatory molecules in mouse endothelium.