背景：Proprotein convertase subtilisin/kexin type 9 （PCSK9）, also known as NARC1 （neural apoptosis regulated convertase）, which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family.
PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species.
It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor （LDLR） protein levels.
Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels.
Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia.
PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
References
仕様
サイズ：100ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_705793.1
アミノ酸配列：Met 1-Gln 694
遺伝子構造：A DNA sequence encoding the full length of mouse PCSK9 （NP_705793.1） precursor （Met 1-Gln 694） was expressed, with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
