背景：Uteroglobin （UG）, also known as Secretoglobin 1A member 1 （SCGB1A1）, Blastokinin, Clara cell secretor protein （CCSP） or Clara cell-specific 10-kDa protein （CC10）, is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals.
This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties.
Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins （C/EBPs） are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription.
Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties.
Uteroglobin inhibits soluble phospholipase A（2） activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins.
In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities.
The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus.
Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target.
The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.
仕様
サイズ：100ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞88 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q06318
アミノ酸配列：Met 1-Phe 96
遺伝子構造：A DNA sequence encoding the mouse SCGB1A1 （Q06318） （Met 1-Phe 96） was expressed, with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Uteroglobin; Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1; Scgb1a1; Cc10; Ugb;CC16;CCSP;PCB-BP;UG;UGB;Utg
分子量：9.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
