背景：Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to theserpin family.
TBG is synthesized primarily in theliveras a 54 kDa protein.TBG is genomically aserpin, although it has no inhibitory function like many other members of this class of proteins.
TBG binds thyroid hormone in circulation.
It is one of three proteins（along with transthyretin and albumin） responsible for carrying thethyroidhormones thyroxine（T4） and 3,5,3'-triiodothyronine （T3） in the bloodstream.
Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration.
Despite its low concentration, TBG carries the majority of T4 inserum.
Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25％ saturated with itsligand.
Unlike transthyretin and albumin, TBG has a single binding site for T4/T3.
TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.
仕様
サイズ：50ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_808588.3
アミノ酸配列：Met 1-Gln 418
遺伝子構造：A DNA sequence encoding the mouse SERPINA7 （NP_808588.3） （Met 1-Gln 418） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：C730040N12Rik;Tbg
分子量：46.2 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
