背景：Interleukin-17 receptor （IL-17R）, also known as Interleukin-17 receptor A （IL-17RA） and CD217 antigen （CD217）, is a cytokine receptor which binds interleukin 17.
IL-17R/IL-17RA （CD217） is a proinflammatory cytokine secreted by activated T-lymphocytes.
It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils.
IL-17R/IL-17RA （CD217） is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A.
Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.
Like other cytokine receptors, this receptor likely has a multimeric structure.
Defects in IL-17R/IL-17RA （CD217） are the cause of familial candidiasis type 5 （CANDF5）.
CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida.
It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞98 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_032385.1
アミノ酸配列：Met 1-Trp 322
遺伝子構造：A DNA sequence encoding the mouse IL17RA （NP_032385.1） extracellular domain （Met 1-Trp 322） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：AW538159;Cdw217;Il17r;VDw217
分子量：34.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
