背景：Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 （TRAIL R2）, is a member of the TNF-receptor superfamily, and contains an intracellular death domain.
This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand （TNFSF10/TRAIL/APO-2L）, and transduces an apoptosis signal.
Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL.
TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor （TNFR） family members, and a cytoplasmic death domain.
TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1.
TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family.
Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas （HNSCC） also known as squamous cell carcinoma of the head and neck.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_064671.2
アミノ酸配列：Met 1-Ser 177
遺伝子構造：A DNA sequence encoding the extracellular domain of mouse TNFRSF10B （NP_064671.2） （Met 1-Ser 177） was expressed, with a C-terminal polyhistidine tag.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
