背景：Insulin-like growth factor binding protein 6 （IGFBP6） is a 24-kDa protein that binds insulin-like growth factor 1 （IGF-1） and IGF-2 with high affinity and inhibits IGF action in vitro.
The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1.
IGFBPs are clearly distinct but are sharing regions with strong homology.
All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity.
Insulin-like growth factor （IGF） binding proteins （IGFBPs） have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate.
IGF-binding protein-4 （IGFBP-4） inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall.
IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors.
There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.
仕様
サイズ：100ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞92 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_032370.2
アミノ酸配列：Met 1-Gly 238
遺伝子構造：A DNA sequence encoding the mouse IGFBP6 （NP_032370.2） （Met 1-Gly 238） was expressed, with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：IGFBP-6
分子量：24 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
