背景：Inducible costimulator （ICOS）, also called AILIM （activiation-inducible lymphocyte immunomediatory molecule） is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1.
The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T＆minus;B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4.
In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells.
The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses.
ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development.
Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9WVS0
アミノ酸配列：Met 1-Leu 142
遺伝子構造：A DNA sequence encoding the mouse ICOS （Q9WVS0） extracellular domain （Met 1-Leu 142） was fused with the Fc region of human IgG1 at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
