背景：Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor （OSMR） and Interleukin-31 receptor subunit beta （IL-31RB）, is one of the receptor proteins for oncostatin M.
OSMR is a member of the type I cytokine receptor family.
IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.
Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis.
Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 （PLCA1）, also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis.
PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition.
This condition usually presents with itching （especially on the lower legs） and visible changes of skin hyperpigmentation and thickening （lichenification） that may be exacerbated by chronic scratching and rubbing.
The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O70458-1
アミノ酸配列：Met 1-Leu 738
遺伝子構造：A DNA sequence encoding the mouse OSMR （O70458-1） extracellular domain （Met 1-Leu 738） was expressed, fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：OSMRB
分子量：83.7 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
