背景：Carboxylesterase 2 （CES2） is a member of the carboxylesterase family and belongs to the multigene family.
Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin.
It also serves to hydrolyze long-chain fatty acid esters and thioesters.
It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation.
Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
仕様
サイズ：50ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_663578.1
アミノ酸配列：Met 1-Lys 557
遺伝子構造：A DNA sequence encoding the extracellular domain of mouse CES2 （NP_663578.1） （Met 1-Lys 557） was expressed, with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：ces2A3
分子量：60.4 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
