背景：Vascular endothelial growth factor receptor 3 （VEGFR3）, also known as FLT-4, together with the other two members VEGFR1 （FLT-1） and VEGFR2 （KDR/Flk-1） are receptors for vascular endothelial growth factors （VEGF） and belong to the class III subfamily of receptor tyrosine kinases （RTKs）.
The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis.
Mutations in VEGFR3 have been identified in patients with primary lymphoedema.
The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer （NSCLC）, and so on.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P35917-1
アミノ酸配列：Met 1-Glu 775
遺伝子構造：A DNA sequence encoding the mouse FLT4 （P35917-1） extracellular domain （Met 1-Glu 775） was expressed, with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：AI323512;Chy;Flt-4;VEGFR-3;VEGFR3
分子量：86.4 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
