背景：Hepatocyte growth factor receptor （HGFR）, also known as c-Met or mesenchymal-epithelial transition factor （MET）, is a receptor tyrosine kinase （RTK） that has been shown to be overexpressed and/or mutated in a variety of malignancies.
HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand.
Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin.
Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_032617.2
アミノ酸配列：Met 1-Asn 929
遺伝子構造：A DNA sequence encoding the mouse MET （NP_032617.2） extracellular domain （Met 1-Asn 929） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：AI838057;c-Met;HGF;HGFR;Par4
分子量：102 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
