背景:The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution.
The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer.
The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome.
Bleomycin (BLM), a clinically used glycopeptide anticancer agent.
BLMH is an essential protectant against BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity.
Sequencing revealed several putative sites phosphorylated by different types of protein kinases, but no signal sequence, transmembrane domain, N-linked glycosylation site or DNA-binding motif.
仕様
サイズ:50ug
種由来:Mouse
発現宿主:E.coli
純度:>95 % as determined by reducing SDS-PAGE.
エンドトキシン濃度:Please contact us for more information.
アクセッションNo.:NP_848760.1
アミノ酸配列:Asn 2-Glu 455
遺伝子構造:A DNA sequence encoding the mouse BLMH (NP_848760.1) (Asn 2-Glu 455) was expressed, with a polyhistide tag at the N-terminus.
保存条件:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.