84-9371-13　Recombinant Mouse CD122/IL-2RB Protein （His Tag） 50ug　PKSM040485

特徴

• 背景：Interleukin-2 receptor （IL-2R） also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses.
• CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2.
• The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction.
• The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer.
• Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
• CD122/IL-2RB expression was restricted to the earliest B220+ cells （CD43+CD24-; prepro B cells; fraction A） that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15.
• The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages.
• CD122/IL-2RB plays a role in regulating normal lymphocyte development.