特徴
- 背景：The CD146 antigen, also known as melanoma cell adhesion molecule （MCAM） and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily.
- CD146 contains the characteristic immunoglobulin-like domains （V-V-C2-C2-C2）, a transmembrane region and a short cytoplasmic tail.
- The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.
- As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition.
- This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：＞98 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：Q8R2Y2-1
- アミノ酸配列：Met 1-Val 563
- 遺伝子構造：A DNA sequence encoding the mouse MCAM （Q8R2Y2-1） extracellular domain （Met 1-Val 563） was expressed, fused with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：1-gicerin;AV025631;CD146;CD149;Muc18;s-endo;s-gicerin
- 分子量：61.3 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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84-9371-12
Recombinant Mouse CD146/MCAM Protein （His Tag） 50ug
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