背景：CD137 （also known as 4-1BB） is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor （TNF） receptor superfamily.
It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand （4-1BBL） expressed on several antigen-presenting cells such as macrophages and activated B cells.
Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor＆ndash;associated factors （TRAFs）, the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production.
4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.
In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors.
Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001070976.1
アミノ酸配列：Met 1-Leu 211
遺伝子構造：A DNA sequence encoding the mouse TNFRSF9 （NP_001070976.1） （Met 1-Leu 211） was fused with the Fc region of human IgG1 at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
