背景：FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor （IgE receptor）.
IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen （antigen） molecule.
A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response.
IgE receptor is comprised of an alpha subunit（FcERI）, a beta subunit, and two gamma subunits.
FcERI is glycosylated and contains 2 Ig-like （immunoglobulin-like） domains.
仕様
サイズ：1mg
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P20489
アミノ酸配列：Met1-Gln204
遺伝子構造：A DNA sequence encoding the mouse FCER1A （P20489） （Met1-Gln204） was expressed, fused with the Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：Fce1a;fcepsilonri;FcERI;Fcr-5
分子量：48 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
