背景：Tissue factor pathway inhibitor-2 （TFPI2）, a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor （TFPI）.
It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail.
TFPI2 inhibits plasmin-dependent activation of several metalloproteinases.
TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas.
The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms.
TFPI2 inhibits the tissue factor/factor VIIa （TF/VIIa） complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin.
TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis.
TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.
仕様
サイズ：50ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞83 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O35536
アミノ酸配列：Met1-Lys211
遺伝子構造：A DNA sequence encoding the mouse TFPI2 （O35536） （Met1-Lys211） was expressed, fused with the Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：AV000670;PP5/TFPI-2
分子量：48.4 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
