背景：DPP7 （dipeptidylpeptidase 7）, also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes.
Dipeptidyl peptidases （DPPs） have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins.
DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer.
DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells.
DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26.
It localizes to lysosomes.
DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides.
In response to calcium release, it can be secreted in its active form.
It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
仕様
サイズ：50ug
種由来：Mouse
発現宿主：HEK293 Cells
純度：＞92 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9ET221
アミノ酸配列：Met1-Arg 506
遺伝子構造：A DNA sequence encoding the mouse DPP7 （Q9ET221） （Met1-Arg 506） was expressed, with a C-terminal polyhistidine tag.
別名（遺伝子名）：Dpp2;DPPII;QPP
分子量：53.7 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
